sylfirm_Gold
sylfirm-logo

Comprehensive Fractional RF Microneedling System

Accurate And Powerful Hyper Pluse Effect

Sylfirm uses repeated short pulses that specifically targeting on abnormal blood vessels, Remodeling basement membrane, and dermal rejuvenation that positively influences on redness, vascular region, PIH, and melasma.

FEATURES

What is basement membrane?

The basement menbrane is the very first skin layer made from the embryo, and essential part of the skin that acts as a nutrient supply to the skin. The aging of the skin is started from losing elasticity with the weak basement membrane.

PATHOLOGIC STUDY

Reduction of senescent cells is associated with improvement of pigmentation. Clinical photographs of participants at baseline, 8wks and 12wks of microneedle fractianal radiofrequency treatment, showing gradual improvement in pigmentation. Changes in the number of p16 INK4A-positive cells and expression of prodollangen-1 and melanin pigmentation in lesional skinafter RF treatment. The scal bar indicates 200µm

source : Kang HY. et al. Senescent fibroblasts in melasma pathophysiology. Exp Dermatol. 2018;03. https://doi.org/10.1111/exd13814

HISTOROGIC STUDY

Efficacy of hyper pulsed RF on basment menbranes. increased type IV collagen fiber along the basement membrane (BM) on post-treatment day 7 and 14, PAS stain.

Transmission electron microscopic features of basement membranes. Remarkable thickening of lamina densa on post-treatment day 7 and 14.

***BK, basal keratimocyte; D, dermis; HD, hemidesmosome; KF, keratin filament; LD, lamina densa.

Efficacy of Hyper Pulsed RF on vascular components. Pathogenic(Abnormal) and collapsed blood vessels in dermis and distended blood vessels in subcutaneous fat on day 7 and 14.

*Cho SB, Na j, Zheng Z, et al. in vivo skin reactions from pulsed-type, bipolar,
alternationg current radiofrequency treatment using invasive noninsulated
electrodes. Skin Res Technol. 2018;00:1-8. https://doi.org/10.1111/str.12433

  • Therapeutic Effects of Electro-Magnetic Singnal on Vascular Stuctures

Clinical Results

<Experimental dermatology Published>

Senescent fibroblasts in melasma pathophysiology

Author:H.Y.Kang (Department of Biomedical Science, The Graduate School, Ajou University, Suwon, South Korea)

Background and Objectives

Understanding correlation between Melasma and senes-cent fibroblasts.

Materials and Methods

Study1 – Verification of the number of senescent fibroblasts and distribution in Melasma skin.
Study2 – Verification of the efficacy of SYLFIRM treatment in Melasma skin. 

Results of study

Study1 – Verification of the number of senescent fibroblasts and distribution in Melasma skin. Study2 – Verification of the efficacy of SYLFIRM treatment in Melasma skin.

Details of study

<Theranostics, Published>

Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo

Author: H.Y. Kang (Department of Biomedical Science, The Graduate School, Ajou University, Suwon, South Korea)

Background and Objectives

Identifying the impact of senescent fibroblasts on ageing pigmentation Verifying the effect of remo-ving senescent fibroblasts via SYLFIRM treatment.

Materials and Methods

Study1 – Verification of the number of senescent fibro- blasts and distribution in Lentigo Senilis

Study2 – Verification of the efficacy of SYLFIRM treat- ment in Lentigo Senilis

Results of study

Senescent fibroblasts promote pigmentation and cause deficiency of SFD1. SYLFIRM treatment can be used to increase SDF1 and help toning effect by removing senescent fibroblasts in Lentigo Senilis.

※SDF1 : A kind of the stem cells helpful for toning effect

Details of study

PUBLISHED ARTICLES

Scarlet is a proven product in several paners.

Sylfirm PUBLISHED ARTICLES01

Published by Experimental Dermatology;

Kang, HY, Kim, M et al.
Senescent Fibroblasts in Melasma Pathophysiology
Experimental Dermatology, 2018

Sylfirm PUBLISHED ARTICLES02

Published by Skin Research and Technology

Cho,SB. et al.
In vivo skin reactions from pulsed-type, bipolar, alternating current radiofrequency treatment using invasive noninsulated electrodes.
Skin Res Technol. 2018, 24(2):318-325

Sylfirm PUBLISHED ARTICLES03

Published by Theranostics

Kang, HY. Et al.
Senescent Fibroblasts Drive Ageing Pigmentation: A Potential Therapeutic Target for Senile Lentigo
Theranostics 2018, Vol. 8, Issue 17

Sylfirm PUBLISHED ARTICLES04

Published by PRS

Ahn, TH, Cho,SB. et al.
Adjuvant Therapy for Revision Rhinoplasty of Contracted Nose Using Polydeoxyribonucleotide and Invasive Bipolar Radiofrequency.
Plast Reconstr Glob Open 2018, 6(1): e1645

Sylfirm PUBLISHED ARTICLES02

Published by KSLMS / Medical Lasers;

Ahn, TH, Cho,SB.
Invasive Pulsed-type, Bipolar, Alternating Current Radiofrequency Treatment Using Microneedle Electrodes for Nasal Rosacea.
Med. LASER., 2017; 6(1):32-36

Sylfirm PUBLISHED ARTICLES06

Published by KSLMS / Medical Lasers;

Kang, JS. Et al.
Improvement of Periorbital Wrinkles Treated with an Invasive Non-insulated Microneedle Pulsed Electric Signal device
Med. LASER., 2017; 5(1):34-38

Sylfirm PUBLISHED ARTICLES07

Published by KSLMS / Medical Lasers;

Kim, HM. Et al.
Therapeutic Efficacy and Safety of Invasive Pulsed-Type Bipolar Alternating Current Radiofrequency on Melasma and Rebound Hyperpigmentation.
Med. LASER., 2017; 6(1):17-23

Sylfirm PUBLISHED ARTICLES08

Published by SCIENTIFIC REPORTS;

Na, JJ, Cho,SB.
Electromagnetic Initiation and Propagation of Bipolar Radiofrequency Tissue Reactions via Invasive Non-Insulated Microneedle Electrodes
Sci Rep. 2015; 5; 16735

Sylfirm PUBLISHED ARTICLES09

Published by KSLMS / Medical Lasers;

Cho, SB. Et al.
High-Frequency Alternating Electrical Current: Selective Electromagnetic Tissue Reaction
Med. LASER., 2016; 5(1):1-6